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Effect of food on absorption of erythromycin a study of 2 derivatives the stearate and the base



Effect of food on absorption of erythromycin a study of 2 derivatives the stearate and the base



Journal of Antimicrobial Chemotherapy 5(5): 591-600



Two erythromycin derivatives, the stearate and the enteric-coated base, were given in a cross-over study to fasting and non-fasting [human] volunteers. The stearate gave higher plasma concentrations in non-fasting than in fasting subjects. The area under the curve was significantly larger during steady state day 7 than after a single dose. The base showed larger individual variations in concentrations. Release of the drug from enteric-coated tablets was depressed by food but absorption was not prevented.

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Accession: 005239840

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