EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of food restriction dehydroepi androsterone or obesity on the binding of tritium labeled 7 12 di methyl benz a anthracene to mouse skin dna


Journals of Gerontology 38(1): 8-12
Effect of food restriction dehydroepi androsterone or obesity on the binding of tritium labeled 7 12 di methyl benz a anthracene to mouse skin dna
Whether a reduction in body weight in laboratory mice by regimens that appear to delay the rate of aging (i.e., food restriction and chronic dehydroepiandrosterone (DHEA) treatment), or a production of obesity by the presence of the ob (obese) gene or by gold thioglucose-induced hyperphagia alter the rate of binding of 3H-7,12-dimethylbenz(a)anthracene (3H-DMBA) to mouse skin DNA was studied. Treating A/J mice with food containing 0.6% DHEA for 10 wk or reducing the food intake of non-DHEA treated mice to 60% of ad lib fed animals significantly reduces the amount of 3H-DMBA bound to mouse skin DNA 12 h after a topical application of the carcinogen. A/J mice made obese by a gold thiogluocse-induced hyperphagia and C57BL/6J mice with the ob mutation bind significantly increased amounts of 3H-DMBA to skin DNA when compared to their nonobese counterparts.


Accession: 005239906



Related references

Dehydroepi androsterone and 3 beta methyl androst 5 en 17 one inhibitors of 7 12 di methyl benz a anthracene initiated and 12 o tetradecanoyl phorbol 13 acetate promoted skin papilloma formation in mice. Carcinogenesis (Oxford) 5(4): 463-466, 1984

Effect of hormone manipulation on oxidation reduction and sulfurylation of dehydroepi androsterone and estrone in 7 12 di methyl benz a anthracene induced rat mammary tumors. British Journal of Cancer 41(1): 123-129, 1980

Entero hepatic circulation of 7alpha tritium dehydroepi androsterone sulfur 35 sulfate 7 tritium dehydroepi androsterone carbon 14 glucuronoside and free 7alpha tritium dehydroepi androsterone in the human. Experientia (basel): 480-481, 1967

Purity of tritium labeled poly cyclic aromatic hydro carbons identification of tritium labeled 5 6 di hydro di benz a h anthracene as the major radioactive component in commercial tritium labeled di benz a h anthracene. Analytical Biochemistry 117(1): 208-212, 1981

Effect of food restriction, dehydroepiandrosterone, or obesity on the binding of 3H-7,12-dimethylbenz(a)anthracene to mouse skin DNA. Journal of Gerontology 38(1): 8-12, 1983

Protective effect of dehydroepi androsterone against afla toxin b 1 induced and 7 12 di methyl benz a anthracene induced cyto toxicity and transformation in cultured cells. Cancer Research 35(9): 2482-2487, 1975

Effect of age of nonskin tissues on susceptibility of skin grafts to 7 12 di methyl benz a anthracene carcinogenesis in balb c mice and effect of age of skin graft on susceptibility of surrounding recipient skin to 7 12 di methyl benz a anthracene. Journal of the National Cancer Institute 58(4): 1057-1060, 1977

A simple method for the synthesis of specific deuterium labeled and tritium labeled methyl hydroxylated derivatives of 7 12 di methyl benz a anthracene. Journal of Labelled Compounds & Radiopharmaceuticals 16(6): 819-832, 1979

Inhibition of 7 12 di methyl benz a anthracene induced and urethane induced lung tumor formation in a j mice by long term treatment with dehydroepi androsterone. Carcinogenesis (Oxford) 2(12): 1335-1338, 1981

Tumor initiating activities of various derivatives of benz a anthracene and 7 12 di methyl benz a anthracene in mouse skin. Jones, Pd P. Leber (ed.). Polynuclear Aromatic Hydrocarbons: 3rd International Symposium On Chemistry And Biology; Carcinogenesis And Mutagenesis, Columbus, Ohio, Usa, Oct., . Xxvi 892p. Ann Arbor Science Publishers, Inc: Ann Arbor, Mich., Usa. Illus. P753-764, 1979