Effect of gmp on glucose oxidation and epinephrine stimulated lipolysis in isolated rat epididymal fat cells

Takeda, M.; Nakaya, Y.

Journal of Biochemistry (Tokyo) 80(4): 717-722


Accession: 005241980

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The cGMP increase in isolated rat epididymal fat cells more than doubled 10 min after addition to the cells of carbamylcholine (10-6 M) in the presence or absence of epinephrine (5 .times. 10-7 M). Addition of carbamylcholine, cGMP or dibutyryl cGMP (10-9 to 10-5 M) did not affect glucose oxidation or epinephrine-stimulated lipolysis of the cells. No significant change in the cGMP level was detected 2 min or 10 min after addition of insulin (1 mU/ml) to the cells, when glucose oxidation was stimulated and lipolysis induced by epinephrine was inhibited. The transient increase in the cGMP level in the cells on treatment with carbamylcholine is apparently not sufficient for expression of the effects of insulin.