Effect of hemo dilution on arterial blood pressure central venous pressure intra cranial pressure and intra ocular pressure in pigs
Horven, I.; Lundar, T.; Lilleaasen, P.; Hysing, E.; Stokke, O.
Scandinavian Journal of Thoracic and Cardiovascular Surgery 15(3): 273-278
ISSN/ISBN: 0036-5580 Accession: 005243310
During open-heart surgery, hemodilution is performed before extracorporeal circulation is started by the sampling of autologous blood and substituting an electrolyte solution. Following extracorporeal circulation, first the machine blood and then the autologous blood is reinfused. The hemodilution and reinfusion procedures lead to alterations in blood osmolality and tissue fluid distribution, initiating changes in arterial blood pressure, central venous pressure, intracranial and intraocular pressures. These changes were studied in pigs. These potentially hazardous pressure alterations can be minimized through proper handling of the procedure. Some of the mechanisms involved relevant not only in open-heart surgery, but also in the volume therapy of patients in hypovolaemic shock.