Effect of hydrocortisone and cholinolytics on the resistance of rat red blood cells to hypo osmotic hemolysis

Nezhentsev, M.V.

Farmakologiya i Toksikologiya 44(2): 188-191


Accession: 005244764

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Hydrocortisone, gangleron and benzohexonium at a concentration of 10-6 M increase the resistance of rat red cells to hypoosmotic hemolysis. Diplacin, d-tubocurarine, methamyzil and methacin at the same concentration produce no effect. Repeated hydrocortisone injections to rats decrease the osmotic resistance of red cells; diplacin and d-tubocurarine increase it. Combined use of hydrocortisone and cholinolytics revealed the ability of diplacin and d-tubocurarine to reduce the effect of the steroid on the osmotic resistance of red cells both in vitro and in vivo.