Effect of hydrocortisone and corticotropin on the activity of enkephalin hydrolyzing peptidases in the rat brain

Kalinskaya, L.N.; Kononenko, V.Ya

Doklady Akademii Nauk Ukrainskoi SSR Seriya B Geologicheskie Khimicheskie i Biologicheskie Nauki 10: 56-58


Accession: 005244765

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Hydrocortisone and corticotropine have been studied for their effect on the activity of enkephaline hydrolyzing enzymes in rat hypothalamic membrane fraction and in membrane fractions of corpus striatum and medulla oblongata. The activity of hypothalamic enkephaline hydrolyzing enzymes decreases one hour after a single administration of hydrocortisone and corticotropine. Hydrocortisone administration induces a decrease in the activity of aminopeptidase and peptidyldipeptidase while corticotropine administration-in the activity of enkephalinase A, enkephalinase B, aminopeptidase and peptidyldipeptidase. No pronounced changes in the activity of enkephaline- hydrolyzing peptidases have been revealed in corpus striatum and medula oblongata.