Effect of hydrolytic enzymes on influenza a virus ribo nucleo protein

Smirnov, Y.A.; Kolodkina, V.P.; Kaverin, N.V.

Voprosy Virusologii 4: 477-481


ISSN/ISBN: 0507-4088
Accession: 005244945

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The interaction of protein and RNA in virion ribonucleoprotein (RNP) of influenza A virus was studied by treatment of this structure with the hydrolytic enzymes, pancreatic RNase A, nuclease S1 and pronase. RNA in RNP apparently does not shield proteins from the effect of pronase. The possibility of using this fact in the construction of a model RNP structure is discussed. No differences in the effect of RNase A and nuclease S1 on RNP were found which corresponded to the concept of the protective role of RNP protein in the process of RNA hydrolysis.