Effect of hydroperoxides on the stability of some oily solutions for injection

Pavlov, V.M.; Gol'denberg V.I.

Khimiko-Farmatsevticheskii Zhurnal 19(4): 462-465


Accession: 005244948

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The interaction of the drugs teturam, nitazole and ftorphenasine-decanoate with hydroperoxides the products of oil oxidation was studied in peach and olive oils. These peroxides decrease the stability of oily solutions for the injection of the drugs. A method was proposed for the thermal destruction of the peroxides at 160.degree. C in N2 atmosphere. The kinetics of this process was studied. Solutions for injection with a shelf life more than 2 yr were obtained.