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Effect of intra venous l alanine administration on plasma glucose insulin and glucagon blood pyruvate lactate and beta hydroxy butyrate concentrations in new born infants study in term and preterm new born infants



Effect of intra venous l alanine administration on plasma glucose insulin and glucagon blood pyruvate lactate and beta hydroxy butyrate concentrations in new born infants study in term and preterm new born infants



Acta Paediatrica Scandinavica 67(3): 297-302



Term [10] and preterm [11] newborn infants with appropriate weights for their gestational age were infused for 1 min with L-alanine (150 mg/kg) at the age of 29-76 h (mean 48 h) and circulating levels of glucose, lactate, pyruvate, D-.beta.-hydroxybutyrate (D-BOHB), insulin and glucagon were monitored. Plasma glucose concentrations increased from 2.7 .+-. 0.16 (mean .+-. SEM [standard error of the mean]) to 3.7 .+-. 0.2 mmol/l after 50 min (P < 0.01) in term infants. In preterm infants, after an initial decrease of the glucose level from 3.1 .+-. 0.16 to 2.6 .+-. 0.16 mmol/l (P < 0.05), it returned to the baseline level at 50 min: 3.0 .+-. 0.2 mmol/l. The blood concentration of D-BOHB decreased in term infants from 192 .+-. 37 to 112 .+-. 6 .mu.M/l (P < 0.01) after 40 min. In preterms, its decrease was not significant (P > 0.05). Plasma glucagon levels rose from 53 .+-. 5 to 70 .+-. 8 pmol/l after 10 min (P < 0.01) in term infants and from 61 .+-. 6 to 75 .+-. 9 after 20 min (P < 0.01) in preterm infants. There were no significant changes in plasma insulin concentrations in either group. Forty minutes after L-alanine infusion I/G [insulin/glucagon] ratios were lower in preterm infants (1.26 .+-. 0.14) than in term infants (1.71 .+-. 0.25) (P < 0.01). There was no relationship between the glycemic responses to L-alanine and the basal levels of D-BOHB. The glycemic effect of L-alanine infusion and circulating glucagon may depend upon a specific stage in maturation. The antiketogenic effect of L-alanine infusion is observed in term infants as in adults.

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Accession: 005248257

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PMID: 654907


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