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Effect of levamisole on cell sensitivity in rats with experimental Heymann's nephritis



Effect of levamisole on cell sensitivity in rats with experimental Heymann's nephritis



Acta Medica Hungarica 41(2-3): 137-141



The development of cell-sensitization to renal antigen in rats with experimental Heymann's glomerulonephritis [GN] and the effect of levamisole on cell sensitivity were studied. Morphologic changes in GN rats appeared after 14 days and were most pronounced on days 21-28, with focal proliferation of glomerular cells, an increase of mesangium, a focal increase of the basal membrane material. After day 49 the changes improved slightly and were still the same on day 147 when a location of IgG to the glomerular basal membrane was detected. In every GN rat, cell-sensitivity to renal antigen was revealed from day 21 of the experiment till its end. Levamisole treatment decreased renal morphologic changes and abolished cell-sensitivity to renal antigen. The possible mechanisms of preventing the development of cell-sensitization in rats treated with levamisole are discussed.

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Accession: 005250306

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PMID: 6379593


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