+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of levamisole on cell sensitivity in rats with experimental Heymann's nephritis

Effect of levamisole on cell sensitivity in rats with experimental Heymann's nephritis

Acta Medica Hungarica 41(2-3): 137-141

The development of cell-sensitization to renal antigen in rats with experimental Heymann's glomerulonephritis [GN] and the effect of levamisole on cell sensitivity were studied. Morphologic changes in GN rats appeared after 14 days and were most pronounced on days 21-28, with focal proliferation of glomerular cells, an increase of mesangium, a focal increase of the basal membrane material. After day 49 the changes improved slightly and were still the same on day 147 when a location of IgG to the glomerular basal membrane was detected. In every GN rat, cell-sensitivity to renal antigen was revealed from day 21 of the experiment till its end. Levamisole treatment decreased renal morphologic changes and abolished cell-sensitivity to renal antigen. The possible mechanisms of preventing the development of cell-sensitization in rats treated with levamisole are discussed.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 005250306

Download citation: RISBibTeXText

PMID: 6379593

Related references

Effect of Jingjielianqiao decoction on healing of skin ulcer in rats. Di 1 Jun Yi Da Xue Xue Bao 25(12): 1558-9 1562, 2005

Accelerated norepinephrine turnover in peripheral tissues after ventromedial hypothalamic stimulation in rats. Brain Research 481(2): 298-303, 1989

Effects of cyclosporin A on erythropoietin production by the human Hep 3B hepatoma cell line. Blood 82(3): 978-984, 1993

Heymann nephritis induced by kidney brush border glyco proteins. Laboratory Investigation 43(6): 547-555, 1980

Tissue lipoprotein lipase activity and its action in lipoprotein metabolism. International Journal of Biochemistry 13(5): 525-541, 1981

Monocyte interleukin 2 receptor subunits are differentially upregulated by interferon gamma and interleukin 2. Cytokine 3(5): 460, 1991

Detection of glomerular and nonglomerular bleeding. Journal of Pediatrics 104(1): 161, 1984

Effect of flosequinan on symptoms and exercise tolerance in patients in chronic heart failure experience from double blind placebo controlled us multicenter trials. European Heart Journal 13(ABSTR Suppl.): 348, 1992

Antihypertensive Drugs Evaluated In A Controlled Double-Blind Study. Southern Medical Journal 56: 1410-1416, 1963

Effect of simvastatin on lipid lowering and renal protection in Heymann nephritis rats. 2007

Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America 98(7): 4084-4088, 2001

Effect of plasma on the degradation of hydroperoxides of unesterified linoleic acid and copper-peroxidized LDL. Free Radical Biology and Medicine. 16(4): 459-463, 1994

The effect of cytokinins with purine and phenylurea structure on sugar beet productivity. Fiziologiya na Rasteniyata 14(2): 48-53, 1988

Effect of renal nerve activity on tubular sodium and water reabsorption in dog kidneys as determined by the lithium clearance method. Acta Physiologica Scandinavica 126(2): 251-257, 1986