Effect of lymphocyte storage conditions on the frequency of chromosome aberrations induced by continuous and fractionated action of thio phosphamide

Yakovenko, K.N.; Kagramanyan, M.S.

Tsitologiya i Genetika 16(2): 46-50


Accession: 005252219

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The frequency of thiophosphamide induced chromosomal aberrations in unstimulated human lymphocytes rises when before the mutagen treatment the cells are kept for 48 h at 37.degree. C, as compared with the variants cultivated without preincubation. A statistically significant increase of the effect is found when the mutagen dose is fractionated.