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Effect of marihuana and placebo marihuana smoking on psychological state and on psycho physiological cardio vascular functioning in anginal patients



Effect of marihuana and placebo marihuana smoking on psychological state and on psycho physiological cardio vascular functioning in anginal patients



Biological Psychiatry 12(2): 255-266



Male anginal patients (10) with angiographically documented coronary artery disease, in a randomized double-blind crossover study, smoked 1 marihuana cigarette (18 mg of .DELTA.-9 tetrahydrocannabinol, THC) on 1 morning and 1 placebo marihuana cigarette (0.05 mg of .DELTA.-9-THC) on a successive morning. Significant increases occurred in average cognitive and intellectual impairment scores, derived from the objective content analysis of 5 min of speech, 30 min after smoking marihuana cigarette as compared to the placebo marihuana cigarette; these scores decreased to near presmoking levels 60 min after smoking. No significant average changes occurred in anxiety or 3 hostility scale scores following smoking marihuana. Sizable individual differences were noted in the psychological responses to marihuana smoking due to personality differences and/or differences in THC pharmacokinetics. Significant psychocardiovascular hemodynamic correlations, measured by ECG, were observed during placebo-marihuana smoking between hostility inward scores and systolic blood pressure and ejection fraction, overt hostility outward scores and diastolic blood pressure, as well as between anxiety scores and stroke volume and left ventricular end-diastolic dimension and left ventricular diastolic volume. These significant psychophysiologic correlations were all eliminated during marihuana smoking. In view of associated findings that marihuana smoking decreased myocardial oxygen delivery, decreased exercise time until the onset of anginal pain, and increased myocardial oxygen demand in anginal patients, the use of marihuana by such patients is clearly inadvisable.

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Accession: 005252747

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PMID: 870096



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