+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of marihuana and placebo marihuana smoking on psychological state and on psycho physiological cardio vascular functioning in anginal patients

Effect of marihuana and placebo marihuana smoking on psychological state and on psycho physiological cardio vascular functioning in anginal patients

Biological Psychiatry 12(2): 255-266

Male anginal patients (10) with angiographically documented coronary artery disease, in a randomized double-blind crossover study, smoked 1 marihuana cigarette (18 mg of .DELTA.-9 tetrahydrocannabinol, THC) on 1 morning and 1 placebo marihuana cigarette (0.05 mg of .DELTA.-9-THC) on a successive morning. Significant increases occurred in average cognitive and intellectual impairment scores, derived from the objective content analysis of 5 min of speech, 30 min after smoking marihuana cigarette as compared to the placebo marihuana cigarette; these scores decreased to near presmoking levels 60 min after smoking. No significant average changes occurred in anxiety or 3 hostility scale scores following smoking marihuana. Sizable individual differences were noted in the psychological responses to marihuana smoking due to personality differences and/or differences in THC pharmacokinetics. Significant psychocardiovascular hemodynamic correlations, measured by ECG, were observed during placebo-marihuana smoking between hostility inward scores and systolic blood pressure and ejection fraction, overt hostility outward scores and diastolic blood pressure, as well as between anxiety scores and stroke volume and left ventricular end-diastolic dimension and left ventricular diastolic volume. These significant psychophysiologic correlations were all eliminated during marihuana smoking. In view of associated findings that marihuana smoking decreased myocardial oxygen delivery, decreased exercise time until the onset of anginal pain, and increased myocardial oxygen demand in anginal patients, the use of marihuana by such patients is clearly inadvisable.

(PDF emailed within 1 workday: $29.90)

Accession: 005252747

Download citation: RISBibTeXText

PMID: 870096

Related references

Effect of marihuana and placebo-marihuana smoking on angina pectoris. New England Journal of Medicine 291(2): 65-67, 1974

Effects of marihuana and placebo marihuana smoking on hemodynamics in coronary disease. Clinical Pharmacology and Therapeutics 18(1): 90-95, 1975

Marihuana smoke chronic toxicity evaluation of marihuana smoking in the cynomolgus monkey. Toxicology Letters (Shannon) 48(1 PART 2): A146, 1979

The effect of long term chronic marihuana use on neuro psychological functioning. International Journal of the Addictions 12(5): 617-624, 1977

Review of Mayor's committee on marihuana: the marihuana problem in the city of New York. sociological, medical, psychological and pharmacological studies. Journal of Abnormal and Social Psychology 40(4): 417-419, 1945

Cardio pulmonary effects of marihuana smoking during exercise. Chest 70(3): 441, 1976

Cannabis sativa marihuana part 3 the rutgers identification for marihuana test a reliable and useful procedure for the detection and identification of marihuana utilizing combined microscopy and thin layer chromatography. Journal of Chromatography 82(1): 151-157, 1973

Cardio vascular responses to marihuana in man. Canadian Federation of Biological Societies Proceedings 16: 45, 1973

A case series of patients using medicinal marihuana for management of chronic pain under the Canadian Marihuana Medical Access Regulations. Journal of Pain and Symptom Management 32(5): 497-501, 2006

Short term neuro psycho pharmacological effects of marihuana smoking in experienced male users. Braude, Monique C And Stephen Szara (Ed ) Pharmacology Of Marihuana, Vols 1 And 2 A Monograph Of The National Institute on Drug Abuse Proceedings Of The Meeting Savannah, Ga , Usa, Dec 3-6, 1974 Xvii+458p(Vol 1 ); Xviii+404p(Vol 2 ) Illus Raven Press: New York, N Y , Usa Isbn 0-89004-067-2 393-412, 1976

The use of marihuana a psychological and physiological inquiry. The Use Of Marihuana A Psychological And Physiological Inquiry 202, 1975

Single and double blind cardio vascular studies of marihuana in man. Clinical Research 20(5): 912, 1972

Changes in anxiety feelings following marihuana smoking. The alternation in feelings of anxiety resulting from the smoking of marihuana (Cannabis sativa L.). British Journal of Addiction to Alcohol and Other Drugs 66(3): 185-187, 1971

Psychological and physiological effects of chronic marihuana administration in man. Psychopharmacology Bulletin 9(4): 28-29, 1973

Comparative effects of smoking marihuana or placebo on human motor and mental performance. Clinical Pharmacology and Therapeutics 11(6): 808-815, 1970