Effect of methionine enkephalin on acid secretion from gastric fistulas and heidenhain pouches in dogs stimulated by pentagastrin pentagastrin plus bethanechol or a meal

Woussen Colle M.C.

International Journal of Tissue Reactions 6(2): 167-174


ISSN/ISBN: 0250-0868
Accession: 005253672

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In dogs with denervated Heidenhain pouches and gastric cannulas the action of met-enkephalin on acid secretion stimulated by a liquid meal, pentagastrin or pentagastrin + bethanechol was studied. Serum gastrin levels were determined during the feeding experiments. Meal-stimulated and pentagastrin-stimulated acid secretion from the gastric fistula were inhibited by met-enkephalin. A rise in pentagastrin-induced acid secretion was observed in the denervated stomach. No significant changes were observed in the postprandial acid response from the pouch to the meal, nor from the main stomach or the pough during stimulation with pentagastrin + bethanechol. Gastrin release was decreased by met-enkephalin during the 1st h following feeding and increased during the 2nd h. Evidently met-enkephalin can either inhibit or stimulate acid secretion in dogs. The inhibition occurs only in the innervated fundic mucosa, and might be explained by a decrease in gastrin release and by a decrease in vagal tone.