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Effect of microbial and tumor cell adaptation to rubomycin on penetration of rubomycin and carminomicin

Antibiotiki (Moscow) 23(9): 837-840

Effect of microbial and tumor cell adaptation to rubomycin on penetration of rubomycin and carminomicin

Anthracycline antibiotics rubomycin (daunomycin) and carminomicin rapidly accumulated in the bacterial and ascitic tumor cells and their intracellular concentrations significantly exceeded the concentrations in the medium. The strains of Straphylococcus aureus and Fisher mouse ascitic lymphadenosis L-5178/P resistant to rubomycin preserved sensitivity to carminomicin. The resistance of the bacterial and tumor strains to rubomycin was accompanied by a significant decrease in the accumulation of rubomycin in the cells. At the same time carminomicin also effectively accumulated in the cells of S. aureus and Fisher ascitic lymphadenosis adapted to rubomycin, the same as in the cells of the parent strains.

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Accession: 005254115

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