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Effect of microbial fractions and vehicle on survival of mice bearing Lewis lung carcinoma






Cancer Treatment Reports 64(12): 1329-1333

Effect of microbial fractions and vehicle on survival of mice bearing Lewis lung carcinoma

Mice bearing pulmonary metastases of the [mouse] Lewis lung carcinoma cells were treated i.v. with a nonviable microbial vaccine following amputation of the primary inoculation site. The vaccine consisted of BCG cell wall skeleton, trehalose dimycolate and endotoxin attached to mineral oil microdroplets. Single and repeated doses ranging from 15-675 .mu.g were tested. Survival was modestly but consistently prolonged by vaccination. A portion of the activity appeared to be due to the Tween saline-oil vehicle. A single low dose (15 .mu.g) was as efficacious as higher or repeated doses.

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Accession: 005254120

PMID: 7471123



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