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Effect of microsomal oxidase inductors with mixed function on immune response in mice induced by heterologous red blood cells






Zhurnal Mikrobiologii Epidemiologii i Immunobiologii (4): 42-46

Effect of microsomal oxidase inductors with mixed function on immune response in mice induced by heterologous red blood cells

In experiments on male white mice immunized with sheep red blood cells, the influence of various substances on the antibody titers and the number of rosette-forming cells in the spleen was studied. These substances, acting as inductors of microsomal oxidases with mixed function (cytochrome P-450 and P-448), are phenobarbital, 3-methylcholanthrene, DDT, diphenine, rifampicin and benzodiazepin derivatives (diazepam and phenazepam). All monooxygenase activity inductors exerted a pronounced immunosuppressive effect. Thus, reciprocal relations between the induction of monooxygenases and the induction of immune response were established. The results are discussed from the viewpoint of the new hypothesis stating that immunity is one of the functions of the general system metabolizing chemical compounds in the body.

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Accession: 005254184



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