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Effect of miscleron clofibrate on di methyl hydrazine induced intestinal tumors in rats


Byulleten' Eksperimental'noi Biologii i Meditsiny 90(9): 350-352
Effect of miscleron clofibrate on di methyl hydrazine induced intestinal tumors in rats
Intestinal tumors were induced in male rats by dimethylhydrazine (14 mg/kg body weight s.c. once a week for 20 wk). Some of the animals received clofibrate per os [by mouth] in a dose of 25 mg a day, 5 times wk. Clofibrate did not influence the developmental frequency of the intestinal tumors, but significantly decreased the number of medium size and large tumors. The possible mechanisms of clofibrate action as well as the use of clofibrate and some related agents in oncology are discussed.


Accession: 005254451



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