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Effect of moderate exercise on urinary 3 methoxy 4 hydroxyphenyl glycol in depressed patients


Pharmakopsychiatrie Neuro-Psychopharmakologie 12(5): 351-356
Effect of moderate exercise on urinary 3 methoxy 4 hydroxyphenyl glycol in depressed patients
This study attempted to clarify sources of artifact in biochemical studies with affective disorders in which 3-methoxy-4-hydroxy phenylglycol (MHPG) is used as a measurement of change in CNS norepinephrine (NE) turnover. Substantial increases in urinary MHPG excretion occurred in 10 of the 11 patients when they increased their level of physical activity (0.5 .+-. .14 mg/12 h vs. 1.54 .+-. .49 mg/12 h). Increases were observed in NE (19.2 .+-. 5.1 .mu.g/12 h vs. 25.2 .+-. 3.7 .mu.g/12 h). In 4 patients in whome CSF MHPG levels were obtained, a consistent increase of MHPG levels was observed during the activity period. Elevation of these metabolites was not correlated with changes in depression as reflected by psychiatric observation and rating scales. A considerable amount of lability in urinary and CSF MHPG levels occurred during an unchanging affective state. Careful controls for activity and stress in psychiatric patients were suggested when urinary MHPG is used as an index of central NE turnover.


Accession: 005254579



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