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Effect of modification of brain serotonin norepinephrine and dopamine on ethanol tolerance






Psychopharmacology 75(3): 231-235

Effect of modification of brain serotonin norepinephrine and dopamine on ethanol tolerance

Rats were permanently depleted of brain dopamine (DA), serotonin (5-HT), 5-HT + norepinephrine (NE) or NE + DA by intraventricular injection of either 5,7-dihydroxytryptamine or 6-hydroxydopamine with or without pretreatment with demethylimipramine. Following 1 wk of recovery from surgery, daily treatment with ethanol (5 g/kg, per os) or isocaloric sucrose was carried out for a period of 20-25 days. Testing at 5-day intervals showed that chronic ethanol treatment produced tolerance to the hypothermic and motor impairing effects of ethanol. Depletion of 5-HT alone retarded tolerance, while depletion of NE or DA alone produced no effect. Combined depletion of both NE and 5-HT completely inhibited tolerance development. The inhibit-on of tolerance development by combined depletion of both NE and 5-HT is discussed in terms of a reciprocal relationship between these 2 systems.

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Accession: 005254615



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