Effect of modifiers of microsomal enzymes on enzymatic denitrosation of dialkyl n nitrosamines
Arshinov, V.Yu; Shulyakovskaya, T.S.
Eksperimental'naya Onkologiya 10(2): 20-22
ISSN/ISBN: 0204-3564 Accession: 005254661
The antioxidant butyl-hydroxytoluene has been shown to increase denitrosation of some dialkyl-N-nitrosamines by the liver microsomes of different lines of rats and to protect against diethyl-N-nitrosamine toxicity. 3-Methylcholanthrene, while decreasing denitrosation of diethyl-N-nitrosamine, increased its toxic effect. This data suggest that enzymatic denitrosation is an effective pathway for the inactivation of dialkyl-N-nitrosamines.