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Effect of momordica charantia karela on blood glucose level of normal and alloxan diabetic rabbits

Effect of momordica charantia karela on blood glucose level of normal and alloxan diabetic rabbits

Pakistan Journal of Scientific & Industrial Research 24(1): 27-30

Hypoglycemic effect of the whole dried and powdered Momordica charantia fruit was studied in normal and alloxan-diabetic rabbits. Four different doses of M. charantia powder i.e., 0.25-0.5, 1.0 and 1.5 g/kg body wt were administered orally after suspending in 1% carboxymethyl-cellulose. In normal rabbits, the 0.25 g/kg dose did not significantly affect the blood glucose level, but 0.5, 1.0 and 1.5 g/kg doess produced significant hypoglycemia. In alloxan-diabetic rabbits the 0.25 and 0.5 g/kg doses did not significantly decrease the blood glucose level. Significant hypoglycemia was produced by 1.0 and 1.5 g/kg doses. The maximum decrease of blood glucose in normal and alloxan-diabetic rabbits occurred at 10 h interval. The time required for the blood glucose to return to normal was usually > 24 h. The whole powdered M. charantia fruit may contain more than one type of hypoglycemic agents. These may be an alkaloid (producing effect only in normal rabbits) and an insulin-like substance which is capable of lowering the blood glucose level in normal and diabetic rabbits.

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