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Effect of monoamine oxidase inhibitor and l dopa on the activity of isolated seminal vesicles of normal and diabetic rats in presence of insulin in vitro






Journal of Drug Research (Cairo) 14(1-2): 45-50

Effect of monoamine oxidase inhibitor and l dopa on the activity of isolated seminal vesicles of normal and diabetic rats in presence of insulin in vitro

In vivo treatment with MAOI [monoamine oxidase inhibitor] and in vitro incubation of isolated seminal vesicles with insulin caused an improvement in contractile responses by 56% in diabetic animals only. Prior L-dopa administration and insulin incubation caused an improvement in the adrenergic response of isolated seminal vesicles in normal and diabetic rats. In the latter group, the improvement reached 41.21%. The observed improvement is due to the combined actions of either insulin and MAOI or insulin and L-dopa.

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Accession: 005254942



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