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Effect of nitrogen supply zinc and salt concentration on kojic acid and versicolorin biosynthesis by aspergillus parasiticus



Effect of nitrogen supply zinc and salt concentration on kojic acid and versicolorin biosynthesis by aspergillus parasiticus



Experimental Mycology 11(3): 206-213



We have compared the effects of variation of culture condition on the biosynthesis of kojic acid and versicolorin A by Aspergillus parasiticus (ATCC 36537). Under permissive conditions, both of the secondary metabolites appear in the culture between 40 and 50 h after conidial inoculation. Kojic acid synthesis is maximal with 0.2% peptone and is depressed by additional peptone or ammonia, with 1% peptone or 50 mM NH+4 almost completely eliminating synthesis. These concentrations of nitrogen source cause a much smaller depression of versicolorin synthesis. Versicolorin production is completely dependent on Zn2+ whereas kojic acid synthesis is unaffected by changes in the concentration of Zn2+ or Fe3+. Certain salts inhibit production of both kojic acid and versicolorin, with nearly complete inhibition by 0.8 M NaCl or by 0.05 M NaOAc.

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Accession: 005257075

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