+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Effect of oral propranolol on rest and exercise left ventricular ejection fraction, volumes, and segmental wall motion in patients with angina pectoris. Assessment with equilibrium gated blood pool imaging



Effect of oral propranolol on rest and exercise left ventricular ejection fraction, volumes, and segmental wall motion in patients with angina pectoris. Assessment with equilibrium gated blood pool imaging



British Heart Journal 45(6): 656-666



The effect of oral propranolol on left ventricular ejection fraction, left ventricular volumes, cardiac output, and segmental wall motion was assessed with multigated blood pool imaging both at rest and during supine exercise in 15 patients with angina pectoris. Propranolol had no effect on resting left ventricular ejection fractions. Before propranolol, they did not change during exercise, whereas after propranolol the ejection fractions increased slightly. Exercise left ventricular ejection fractions increased with propranolol in three patients with resting left ventricular ejection fractions of less than 40 per cent. More specifically, left ventricular end-diastolic volume index, end-systolic volume index, stroke volume index, and cardiac index were not altered significantly at rest or during exercise by propranolol. Exercise left ventricular ejection fractions were increased in five and unchanged in eight patients by propranolol. Those patients with increases in left ventricular ejection fractions had a greater change in left ventricular end-diastolic volume indices and a greater change in left ventricular end-systolic volume indices during exercise while on propranolol. Left ventricular segmental wall motion was not altered significantly during exercise by propranolol. We conclude that: (1) Left ventricular functional responses to propranolol during exercise are heterogeneous and not easily predicted; (2) propranolol causes no consistent deterioration in exercise left ventricular ejection fraction even in patients with resting ventricular ejection fractions less than 40 per cent; (3) increased exercise left ventricular ejection fraction with propranolol is contributed to by significant increases in end-diastolic volume during exercise; and (4) gated blood pool imaging is a useful method for characterising rest and exercise left ventricular ejection fractions and left ventricular volumes during propranolol therapy.

(PDF emailed within 0-6 h: $19.90)

Accession: 005258165

Download citation: RISBibTeXText

PMID: 7259915

DOI: 10.1136/hrt.45.6.656


Related references

Observer variance in the qualitative evaluation of left ventricular wall motion and the quantitation of left ventricular ejection fraction using rest and exercise multi gated blood pool imaging. Circulation 61(1): 128-136, 1980

Left ventricular ejection fraction and volumes from gated blood-pool SPECT: comparison with planar gated blood-pool imaging and assessment of repeatability in patients with heart failure. Journal of Nuclear Medicine 44(4): 494-498, 2003

Asynchronous left ventricular diastolic filling at rest in patients with angina pectoris assessment by multiple gated blood pool imaging. Kaku Igaku 20(9): 1263-1271, 1983

Effect of oral alcohol on left ventricular ejection fraction volumes and segmental wall motion in normals and in patients with recent myocardial infarction. Clinical Cardiology 8(11): 576-582, 1985

Gated blood-pool SPECT versus cardiac magnetic resonance imaging for the assessment of left ventricular volumes and ejection fraction. Journal of Nuclear Cardiology 17(3): 427-434, 2010

Rapid assessment of left ventricular segmental wall motion, ejection fraction, and volumes with single breath-hold, multi-slice TrueFISP MR imaging. Journal of Cardiovascular Magnetic Resonance 8(3): 435-444, 2006

Assessment of regurgitant fraction and right and left ventricular function at rest and during exercise a new technique for determination of right ventricular stroke counts from gated equilibrium blood pool studies. American Heart Journal 104(5 PART 1): 953-962, 1982

Effect of atrial blood pool activity on assessment of left and right ventricular ejection fraction by gated cardiac blood pool imaging. Journal of Nuclear Medicine 23(5): P41, 1982

Evaluation of regurgitant fraction and of right and left ventricular function in patients with valvular regurgitation at rest and during exercise using equilibrium gated blood pool studies. Clinical Nuclear Medicine 5(9 SUPPL): S34-S35, 1980

Asynchronous left ventricular filling in patients with angina pectoris: assessment by multiple gated blood pool imaging. Kaku Igaku. Japanese Journal of Nuclear Medicine 20(9): 1263-1271, 1983

Comparative assessment of rest and post-stress left ventricular volumes and left ventricular ejection fraction on gated myocardial perfusion imaging (MPI) and echocardiography in patients with transient ischaemic dilation on adenosine MPI: myocardial stunning or subendocardial hypoperfusion?. Journal of Nuclear Cardiology 19(4): 735-742, 2012

Evaluation of left ventricular wall motion, volumes, and ejection fraction by gated myocardial tomography with technetium 99m-labeled tetrofosmin: a comparison with cine magnetic resonance imaging. Journal of Nuclear Cardiology 6(1 Pt 1): 3-10, 1999

Left ventricular segmental wall motion gated cardiac blood pool imaging vs 2 dimensional echo cardiography. 1979

Gated blood pool SPECT for measurement of left ventricular volumes and left ventricular ejection fraction: comparison of 8 and 16 frame gated blood pool SPECT. International Journal of Cardiovascular Imaging 21(2-3): 261-266, 2005