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Effect of oxytocin on growth hormone secretion in response to arginine vasopressin in normal men



Effect of oxytocin on growth hormone secretion in response to arginine vasopressin in normal men



Neuroendocrinology Letters 6(3): 137-144



The influence of arginine-vasopressin (AVP) and oxytocin (OT) administration on pituitary growth hormone (GH) secretion was investigated in a group of normal men. AVP in a single i.v. dose produced a prompt increase in plasma GH concentrations. OT administration did not change basal GH-release. In contrast, when the influence of OT on plasma concentrations of GH in response to AVP administration was tested, the secretory peak of GH induced by AVP was significantly lower than that obtained after the administration of AVP alone. AVP and OT interact antagonistically on GH secretion.

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