Section 6
Chapter 5,260

Effect of penetration enhancers on the permeation of mannitol, hydrocortisone and progesterone through human skin

Barry, B.W.; Bennett, S.L.

Journal of Pharmacy and Pharmacology 39(7): 535-546


ISSN/ISBN: 0022-3573
PMID: 2886623
DOI: 10.1111/j.2042-7158.1987.tb03173.x
Accession: 005259720

Mannitol, hydrocortisone and progesterone were selected as model penetrants to assess the mode of action of eight potential penetration enhancers in human skin. Their partition coefficients, octanol:water and stratum corneum:water were measured and correlated with their postulated routes of penetration through human skin. The results suggest that mannitol penetrated via a polar route, hydrocortisone by a mainly lipid route and progesterone via a lipid pathway but its penetration rate was probably affected by aqueous layers. From permeation studies through cadaver skin in which an in-vivo mimic method was used, it was concluded that the penetration enhancers fell into three main categories: (1) solvents which enhanced permeation of polar and non-polar compounds e.g. 2-pyrrolidione, N-methylpyrrolidone, N-methylformamide and propylene glycol plus Azone; (2) enhancers which preferentially affected the polar route e.g. propylene glycol plus decylmethylsulphoxide, and (3) accelerants which mainly modified the non-polar route e.g. propylene glycol plus oleic acid, propylene glycol alone and, to a limited extent, water.

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