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Effect of pre treatment with retinyl acetate on distribution and metabolism of tritium labeled 7 12 di methyl benz a anthracene in female rats



Effect of pre treatment with retinyl acetate on distribution and metabolism of tritium labeled 7 12 di methyl benz a anthracene in female rats



Indian Journal of Experimental Biology 20(11): 845-849



Pretreatment of rats with retinyl-acetate reduced the concentration of DMBA-3H [3H-dimethylbenz(a)anthracene] and/or its metabolites in the liver, mammary gland, spleen, adrenal gland, kidney and blood. A similar effect was observed in all the liver subcellular fractions. TLC of metabolites extracted into lipids from liver and its subcellular fractions revealed the presence of all the hydroxymethyl derivatives of DMBA. Besides these, 2 unidentified derivatives. A and B, could be detected with Sephadex LH-20 column chromatography. The only detectable metabolite in mammary pad was found to be 7-hydroxymethyl-12-methylbenz(a)anthracene. The level of the derivatives, A and B, in liver of control animals at 1.5 and 4 h after the administration of the carcinogen was almost the same whereas in retinyl-acetate pretreated rats their level at 4 h was significantly less than at 1.5 h. In the liver cytosol fraction of pretreated rats, their level was much higher than the control values. The metabolic change in the carcinogen induced by retinyl-acetate could be one of the factors responsible for inhibiting the mammary tumorigenesis induced by DMBA.

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