EurekaMag.com logo
+ Site Statistics
References:
48,252,460
Abstracts:
22,798,453
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of progesterone on cell division in chemically induced endometrial hyperplasia and adeno carcinoma in mice


, : Effect of progesterone on cell division in chemically induced endometrial hyperplasia and adeno carcinoma in mice. Cancer Research 38(1): 78-82

Cotton string coated with 3-methylcholanthrene (MCA) was implanted in the uterine cavity of ICR mice to induce endometrial hyperplasia and adenocarcinoma. A low dose (total, 2.5 mg) or a high dose (total, 35 mg) of progesterone was administered to the mice at various times during a period of 4-40 wk after MCA application. After serial labeling with [3H]thymidine, the mice were sacrificed, and thymidine-labeling index values of endometrial hyperplasia and adenocarcinoma in progesterone-treated and untreated mice were investigated by autoradiographic techniques. In mice implanted with MCA, there was a progressive increase of hyperplasia and neoplasia as a function of time. The low doses of progesterone administered to the mice caused a significant reduction in labeling with [3H]thymidine in nonatypical hyperplasia and moderate atypical hyperplasia, compared to that for untreated mice. In marked atypical hyperplasia and adenocarcinoma, irrespective of the histological grade, labeling was not reduced. With the high dose of progesterone, marked morphological alterations with degenerative changes were observed in atypical hyperplasia and differentiated adenocarcinoma. Cancer cells were still maximally labeled. The results indicate that the effect of progesterone on nonatypical hyperplasia and moderate atypical hyperplasia is mitotic arrest, whereas the effect on marked atypical hyperplasia and adenocarcinoma is morphological and cytological alterations.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 005264198

PMID: 618585

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Anonymous, 2005: Laugh yourself healthy: studies show humor-health link. Journal of the American Veterinary Medical Association 226(12): 1970-1971

Takahashi, T.; Yutani, Y,, 1979: Cultivation of Allium tuberosum under electric light. Selection for suitability for forced cultivation focuses mainly on a low requirement for reduced temperatures to break dormancy and insensitivity to short-day conditions. Of the varieties currently grown, Green Belt is the best adapted to forced c...

Rinne, U.K.; Sonninen, V., 1973: Brain catecholamines and their metabolites in Parkinsonian patients. Treatment with levodopa alone or combined with a decarboxylase inhibitor. Archives of Neurology 28(2): 107-110

Krieger, M.; Goldstein, J.L.; Brown, M.S., 1978: Receptor-mediated uptake of low density lipoprotein reconstituted with 25-hydroxycholesteryl oleate suppresses 3-hydroxy-3-methylglutaryl-coenzyme A reductase and inhibits growth of human fibroblasts. The free and esterified cholesterols of plasma low density lipoprotein (LDL) were extracted with heptane and replaced with 25-hydroxycholesteryl oleate. The resulting particle, designated r-[25-HC oleate]LDL, bound to LDL receptors on human fibrob...

Mitchell P.D., 1968: The time to mow orchards water requirement mulch soil grass. Orchardist of New Zealand 41(11): 403

Goto, Y.; Toyota, T.; Masuda, M.; Komatsu, K.; Kuriki, A., 1976: Natural history of diabetes mellitus with special reference to age of onset and vascular complications. Age and sex distribution of diabetics, seasonal incidence of diabetes, grade of hyperglycemia, frequency of vascular complications and daily living conditions were studied of 2771 diabetic patients experienced at five clinics. The cases consisted...

Song, Z-Chun.; Wang, Z-Sheng.; Bai, J-Hui.; Li, Z.; Hu, J., 2013: Emodin, a naturally occurring anthraquinone, ameliorates experimental autoimmune myocarditis in rats. Myocarditis is an inflammatory disease of the heart and a major cause of dilated cardiomyopathy that can lead to heart failure and sudden death in young adults. Giant cell myocarditis is a severe heart disease of unknown causes and is defined his...

Carmelo Caldarella, Giorgio Treglia, Alfredo Pontecorvi, Alessandro Giordano, 2012: Diagnostic performance of planar scintigraphy using 99mTc-MIBI in patients with secondary hyperparathyroidism a meta-analysis. Parathyroid scintigraphy using <sup>99m</sup>Tc-MIBI is not currently considered a valuable diagnostic tool for the localization of involved glands in patients with secondary hyperparathyroidism (SHPT). However, published data about it...

Xin, J.; Chen, T.; Lin, Z.; Dong, P.; Tan, H.; Li, J., 2015: Phosphorylated dendronized poly(amido amine)s as protein analogues for directing hydroxylapatite biomineralization. Dendronized poly(amido amine)s (DPs) bearing tri-phosphate or bis-phosphonate peripheral groups are synthesized. These worm-like DPs can template the formation of BMSCs adhesive hydroxylapatite (HA) on the nano-scale, or self-assemble into mineral...

Haguenauer, J.P.; Bouvier, M., 1966: Scapulo-humeral periarthritis of the"frozen shoulder"type following cervical lymph node évidement. Rhumatologie 18(6): 231-235