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Effect of progesterone on cell division in chemically induced endometrial hyperplasia and adeno carcinoma in mice

Cancer Research 38(1): 78-82

Effect of progesterone on cell division in chemically induced endometrial hyperplasia and adeno carcinoma in mice

Cotton string coated with 3-methylcholanthrene (MCA) was implanted in the uterine cavity of ICR mice to induce endometrial hyperplasia and adenocarcinoma. A low dose (total, 2.5 mg) or a high dose (total, 35 mg) of progesterone was administered to the mice at various times during a period of 4-40 wk after MCA application. After serial labeling with [3H]thymidine, the mice were sacrificed, and thymidine-labeling index values of endometrial hyperplasia and adenocarcinoma in progesterone-treated and untreated mice were investigated by autoradiographic techniques. In mice implanted with MCA, there was a progressive increase of hyperplasia and neoplasia as a function of time. The low doses of progesterone administered to the mice caused a significant reduction in labeling with [3H]thymidine in nonatypical hyperplasia and moderate atypical hyperplasia, compared to that for untreated mice. In marked atypical hyperplasia and adenocarcinoma, irrespective of the histological grade, labeling was not reduced. With the high dose of progesterone, marked morphological alterations with degenerative changes were observed in atypical hyperplasia and differentiated adenocarcinoma. Cancer cells were still maximally labeled. The results indicate that the effect of progesterone on nonatypical hyperplasia and moderate atypical hyperplasia is mitotic arrest, whereas the effect on marked atypical hyperplasia and adenocarcinoma is morphological and cytological alterations.

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Accession: 005264198

PMID: 618585

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