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Effect of progesterone on the sympathetic response of a frog nerve skin preparation

Cellular & Molecular Biology (Oxford) 31(5): 373-378
Effect of progesterone on the sympathetic response of a frog nerve skin preparation
The action of progesterone (Pg) on the response to electrical stimulation of a frog nerve-skin preparation was tested. The electrical stimulation caused a biphasic variation in the potential difference and in the short circuit current across the skin. The variation consisted of a depolarization wave followed by a hyperpolarization wave, referred to as alpha and beta adrenergic responses, respectively. A dose-related inhibition of the beta response by Pg was observed, Pg also inhibited the beta response to noradrenaline added to the vascular surface of the skin, whereas the alpha response remained unaltered. The preincubation of the preparation with dibutyryl cAMP prevented the Pg inhibition of the beta response. It is concluded that Pg inhibits the beta response at the postsynaptic level. A fall in the ATP pool is proposed as a possible mechanism of the observed effect.

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Accession: 005264224

PMID: 4084942

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