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Effect of prolonged administration of corticotropin releasing factor on plasma concentrations of acth in patients with addison's disease

, : Effect of prolonged administration of corticotropin releasing factor on plasma concentrations of acth in patients with addison's disease. Experimental and Clinical Endocrinology 87(2): 208-210

To investigate the possibility that the prolonged administration of corticotropin releasing factor (CRF) might suppress rather than enhance pituitary ACTH-secretion 24-hour infusion (50 .mu.g/h) of ovine CRF were performed in 6 patients with adrenocortical insufficiency. CRF induced a heterogenous behavior of plasma ACTH concentrations in these hypercorticotropinemic patients but both a sustained increase and a suppression of ACTH was clearly absent at the end of the 24 hour infusion period. Thus, continuous administration of CRF does not appear to be a promising way to control abundance of plasma ACTH concentrations in patients with Addison's disease.

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