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Effect of prolonged hydrocortisone administration on nucleic proteins of regenerating guinea pig liver after partial hepatectomy


Acta Medica Polona 27(1-2): 9-18
Effect of prolonged hydrocortisone administration on nucleic proteins of regenerating guinea pig liver after partial hepatectomy
The effect of prolonged hydrocortisone administration on nucleic proteins (nucleic ribonucleoprotein, ribosomal and nonhistone proteins) of regenerating liver was investigated in guinea-pig. Hydrocortisonum aceticum, Polfa, was administered in the dose 10 mg/100 g of body mass 0.5, 20, 44 and 68 hours after 50-%-hepatectomy. Relative and dry liver mass and increase of liver parenchyma were also estimated. Regenerating liver showed the rise of dry mass. The administration of hydrocortisone lowered the value of the latter. The effect of hydrocortisone on hepatic regeneration consisted in the change of ribosomal proteins of nucleic fraction and of total nucleic protein. Prolonged administration of hydrocortisone increases the amount of ribosomal nucleic protein in the regenerating liver. This parameter usually diminishes during regeneration. The application of 2 variants of protein calculation i.e. in mg/l g of fresh liver and in mg/l g of the dry mass indicates that the effect of hydrocortisone on hepatic regeneration consists in causing the disturbance of cytoplasm-nucleus ratio.


Accession: 005264426

PMID: 3565079



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