EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of prolonged oral administration of thyrotropin releasing hormone on plasma levels of thyrotropin and prolactin in normal individuals and in patients with primary hypo thyroidism


Acta Endocrinologica 85(4): 744-752
Effect of prolonged oral administration of thyrotropin releasing hormone on plasma levels of thyrotropin and prolactin in normal individuals and in patients with primary hypo thyroidism
Forty mg TRH [thyrotropin releasing hormone] per day was given orally for 3 wk to 10 euthyroid women and 10 women with primary hypothyroidism on low replacement doses of thyroxine. Once weekly oral TRH was replaced by an i.v. TRH-test (0.4 mg) with measurement of serum concentration of TSH [thyrotropin], prolactin (PRL), thyroxine (T4), triiodothyronine (T3) and cholesterol. In the normal group, mean serum T4 concentration increased after 1 wk and remained elevated. Serum TSH concentration showed a slight tendency to decline. Maximal rise in TSH concentration after i.v. TRH (.DELTA.TSH) fell from a mean of 4.0 ng/ml to 1.4 ng/ml within 1 wk and stayed low. T3, cholesterol, PRL and .DELTA.PRL were normal and unchanged throughout. In the hypothyroid group T4, T3, cholesterol, PRL and .DELTA.PRL were not influenced by the TRH administration. In 2 patients (with the highest serum T4 concentrations) serum TSH concentration was normal and resistent to i.v. TRH. Of the 8 patients with elevated TSH, basal level and .DELTA.TSH did not change in 2 (with subnormal T4 levels and the highest TSH levels). In the other 6 (with intermediate T4 levels) basal TSH fell from a mean of 10.1 ng/ml to 4.2 ng/ml, and .DELTA.TSH from 10.0 ng/ml to 3.3 ng/ml after 3 wk. In addition to feedback effect of thyroid hormones, the pituitary response to long-term administration of TRH is determined by other factors. Among these may be reduced pituitary TRH receptor capacity and the activity of the TSH producing cells.


Accession: 005264473



Related references

Effect of an oral water load on serum thyrotropin in normal subjects and on thyrotropin and prolactin responses to thyrotropin releasing hormone in patients with primary hypo thyroidism. Journal of Clinical Endocrinology & Metabolism 41(4): 784-787, 1975

The effect of thyrotropin releasing hormone on plasma prolactin and thyrotropin levels in primary hypo thyroidism. Clinical Endocrinology 2(3): 289-295, 1973

Effect of acute increases in serum tri iodo thyronine on thyrotropin and prolactin response to thyrotropin releasing hormone and estimates of pituitary stores of thyrotropin and prolactin in normal subjects and in patients with primary hypo thyroidism. Journal of Clinical Endocrinology & Metabolism 42(3): 443-458, 1976

The effect of synthetic thyrotropin releasing factor on the plasma level of thyrotropin hormone and growth hormone in healthy persons and patients with hyper thyroidism and primary hypo thyroidism. Deutsche Medizinische Wochenschrift 95(52): 2623-2624, 1970

The effect of l dopa administration on thyrotropin and thyrotropin releasing hormone levels in serum in primary or pituitary hypo thyroidism. Endocrinologia Japonica 25(5): 499-502, 1978

Influence of dopaminergic inhibition on serum levels of thyrotropin and prolactin in patients with hypo thyroidism before and after prolonged oral administration of trh. Acta Endocrinologica 104(2): 183-188, 1983

Effect of bovine thyroid stimulating hormone on human plasma thyrotropin levels in primary hypo thyroidism evidence against the short feedback of thyrotropin in man. Journal of Endocrinology 59(1): 189-190, 1973

Effects of substitution with thyroxine on the thyrotropin response to thyrotropin releasing hormone in severe primary myx edema and in mild hypo thyroidism following prolonged thyrostatic therapy. Acta Endocrinologica 89(2): 303-315, 1978

Plasma thyrotropin-releasing hormone, prolactin, thyrotropin, and thyroxine concentrations following the intravenous or oral administration of thyrotropin-releasing hormone. American Journal of Obstetrics and Gynecology 135(6): 737-742, 1979

Oral administration of thyrotropin releasing hormone in puerperal women effect on insufficient lactation thyroid hormones and on the responses of thyrotropin and prolactin to intra venous thyrotropin releasing hormone. Acta Endocrinologica 93(4): 413-418, 1980