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Effect of propranolol on the acid base balance and hemodynamics of 'chronically instrumented' pregnant sheep

, : Effect of propranolol on the acid base balance and hemodynamics of 'chronically instrumented' pregnant sheep. Developmental Pharmacology and Therapeutics 6(3): 207-216

A .beta.-adrenergic blocking agent, propranolol, has been used during pregnancy for treatment of hypertension, cardiac arrhythmias, refractory atrial tachycardia and thyrotoxicosis. Maternal and fetal responses to i.v. admission of propranolol (4 mg/4 min) were investigated in 10 steady-state sheep experiments performed on 5 ewes and their fetuses at 101-128 days of gestation. Observations were made at 0, 5, 15, 30, 45, 60, 75, 90 and 120 min from the start of infusion. Transient decrease in fetal heart rate (P < 0.05) was observed at 15 min, accompanied by fetal acidosis, which persisted throughout the experiment. Mean fetal pCO2 [partial pressure of CO2] increased significantly at 5, 15 (P < 0.025) and 75 min (P < 0.05). Fetal pO2 decreased at 15 min (P < 0.025). O2 saturation (O2%) decreased at 15 (P < 0.001) and 60 min (P < 0.025). Concomitant decreases in O2 content were noted at 15 (P < 0.005), 30 (P < 0.05), 60 (P < 0.025) and 90 min (P < 0.05). Mean fetal base excess decreased at 30 min (P < 0.05). Mean maternal heart rate decreased at 15 (P < 0.010) and 30 min (P < 0.005), followed by an increase at 75 (P < 0.05) and 90 min (P < 0.05). Mean uterine blood flow remained unchanged during infusion and up to 90 min. It increased at 105 (P < 0.025) and 120 in (P < 0.05). Propranolol apparently causes definite fetal adverse effects and its usage during pregnancy must be limited to absolutely indicated situations.

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Accession: 005264675

PMID: 6861606

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