EurekaMag.com logo
+ Site Statistics
References:
48,252,460
Abstracts:
22,798,453
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of prostacyclin infusion during low flow ischemia in the isolated perfused rat heart


, : Effect of prostacyclin infusion during low flow ischemia in the isolated perfused rat heart. Basic Research in Cardiology 79(2): 125-134

Although prostacyclin (PGI2) has been shown to exert a protective effect on ischemic hearts its precise mode of action remains obscure. Possible explanations include protection of the high energy phosphate stores (ATP and CP [creatine phosphate]), maintenance of homeostasis with respect to Ca2+ and an antiaggregatory effect. The following experiments were undertaken to investigate these possibilities, using isolated, spontaneously beating rat hearts perfused with Krebs-Henseleit solution. Ischemia was induced at 37.degree. C for 30 min by reducing the flow rate from 10.0 to 0.1 ml/min, and was followed by reperfusion . PGI2 was given as a constant infusion (20 ng/ml). The hearts were frozen and assayed for ATP and CP, or digested in HNO3 and assayed for Ca2+. Peak developed tension was recorded throughout. PGI2 evidently slowed the rate of decline of developed tension during low flow perfusion and hastened the recovery of contractions on reperfusion. These effects could not be accounted for in terms of an improved supply of ATP or CP, or an altered tissue Ca2+. The protective effect of PGI2 on isolated, buffer-perfused hearts may be a reflection of a generalized, but undefined, mechanism of cell preservation which also has been observed in other systems.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 005264732

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Seo, Toru; Al Haideri, Maysoon; Goldberg, Ira J.; Deckelbaum, Richard J., 1998: Selective uptake of LDL-cholesteryl esters is stimulated by lipoprotein lipase and oleic acid via a calcium independent pathway involving cell surface proteoglycans. Circulation 98(17 SUPPL ): I314, Oct 27

Vanguri, P.; Belen, O., 1993: Ia gene regulation in astrocytes Effect of interferon-gamma and glutamate on XBP, C-jun, C-fos and Ia mRNAs. Journal of Immunology 150(8 PART 2): 206A

Yamamura, S; Sasaki, K; Toda, M; Hirata, Y., 1974: The structure of yuzurine. Tetrahedron letters: 23 2023-2026

Hernandez, A.; Martinez del Rio, C., 1992: Intestinal disaccharidases in five species of phyllostomoid bats. Comparative Biochemistry and Physiology B Comparative Biochemistry, 1031: 105-111

Tumialis, Dorota E-mail: doratumpoczta.onet.pl.; Kamionek, Marta., 2005: Optymalization of liquid conditions of entomopathogenic nematodes Heterorhabditis megidis culturing Optymalizacja warunkow plynnych hodowli nicieni owadobojczych Heterorhabditis megidis. The aim of the study was to determine the optimal parameters i.e. initial dose, aeration to gain stability of the nematodes multiply process, acceleration of their development cycle and obtain its biggest final effectiveness of DI nematodes during...

De Falco, Fabrizio A.; Majello, Luigi; Santangelo, Roberto; Stabile, Mariano; Bricarelli, Franca Dagna; Zara, Federico, 2001: Familial infantile myoclonic epilepsy: Clinical features in a large kindred with autosomal recessive inheritance. Purpose: To describe the clinical features of a large kindred with familial infantile myoclonic epilepsy (FIME) with autosomal recessive inheritance, and to discuss the nosology of the early infantile myoclonic epilepsies (IMEs). Methods: The fami...

Jensen, Teis; Galli Stampino, Luisa; Mouritsen, Soren; Frische, Klaus; Peters, Stefan; Meldal, Morten; Werdelin, Ole, 1996: T cell recognition of Tn-glycosylated peptide antigens. The mouse hemoglobin-derived decapeptide Hb (67-76), VITAFNEGLK, which binds well to E-k and is non-immunogenic in CBA/J mice, was O-glycosylated with the tumor-associated carbohydrate Tn (alpha-D-N-acetylgalactosamine, or alpha-D-GalNAc). Each of...

Dyke, A. J.; Szmidt, R. A. K.; Metcalf, E. D.; Noble, R., 1988: Self-blanching celery: the effect of light and temperature on bolting. Effects of temperature and lighting regimes on bolting of selfblanching celery in both the propagation and growing-on stages were examined over a 4-year period, 1983-1986. Increasing temperature during propagation delayed bolting but the use of ni...

Anonymous, 1992: Temperature sensor locations for seed-cotton drying systems. The purpose of this standard is to provide uniform locations for seed cotton drying system temp. control sensors in cotton gins. Uniform sensor locations will make drying temp. recommendations more meaningful and allow ginners to improve the quali...

Nitzsche, Peter; Fiola, Joseph, 2000: Influence of early rowcover removal and supported rowcovers on yield, earliness, and fruit size of strawberries grown under plasticulture. Hortscience 35(3): 433-434, June