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Effect of prostaglandin d 2 in modulation histamine release from human basophils


, : Effect of prostaglandin d 2 in modulation histamine release from human basophils. Journal of Pharmacology & Experimental Therapeutics 228(2): 400-406

Prostaglandin (PG) D2 is the major cyclooxygenase metabolite of arachidonic acid released after immunologic stimulation of mast cells. This PG is unlike other PG previously investigated in that it enhances human basophil histamine release at concentrations of 1-100 nM. Enhancement is seen when antigen, the phorbol diester, 12-0-tetradecanoylphorbol-13-acetate and ionophore A23187 [calcimycin] are used to initiate release and, in preparations of basophils, purified to 51-66% of total cell number as well as in preparations of mixed leukocytes. This enhancement is a late or second stage phenomenon as defined by the 2 stages of histamine release and is additive with the enhancement produced by D2O, but not with the enhancement produced by indomethacin or 5-hydroperoxyeicosatetraenoic acid. PGD2 also reverses the inhibition of release produced by drugs and hormones such as dimaprit and PGE2 that activate adenylate cyclase to increase cellular cAMP levels. PGD2 may play an important role in allergic and immunologic reactions and a mechanism by which mast cells and basophils can interact during these reactions is suggested.

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