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Effect of prostaglandin d 2 prostaglandin e 2 and prostaglandin f 2 alpha on catecholamine release from slices of rat and rabbit brain






European Journal of Pharmacology 69(4): 421-428

Effect of prostaglandin d 2 prostaglandin e 2 and prostaglandin f 2 alpha on catecholamine release from slices of rat and rabbit brain

Slices of rabbit or rat brain cortex were preincubated with [3H]noradrenaline [norepinephrine], and slices of rabbit caudate nucleus or rat striatum with [3H]dopamine. The slices were then superfused and stimulated electrically. In rat cortex slices, PG[prostaglandin]E2 (0.01-1 .mu.mol/l) markedly reduced the stimulation-evoked tritium overflow PGF2.alpha. (1 .mu.mol/l) caused a slight decrease only after the formation of endogenous PG had been blocked by indomethacin. PGD2 (1 .mu.mol/l) had no effect. In slices of rabbit cortex and caudate nucleus as well as in rat striatal slices, none of the PG (1 .mu.mol/l) caused any change, irrespective of whether the production of endogenous PG was intact or blocked. Apparently, of 3 major PG that occur in the brain, only PGE2 is a potent presynaptic inhibitor of noradrenaline release in the rat. The catecholamine neurons of rabbit brain, and the dopamine neurons of rat striatum, are resistant to these PG.

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Accession: 005264779



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