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Effect of prostaglandin e 1 prostaglandin e 2 and prostaglandin f 2 alpha on neutrophil aggregation

, : Effect of prostaglandin e 1 prostaglandin e 2 and prostaglandin f 2 alpha on neutrophil aggregation. Prostaglandins 17(2): 201-210

Chemotactic factors stimulate neutrophils in suspension to aggregate. Because of an obvious analogy to platelet aggregation, the influence of 3 prostaglandins on this process were examined. Prostaglandins[PG]E1, E2 and F2.alpha. alone did not cause aggregation of the [human] neutrophils but were able to partially inhibit the aggregation response induced by the synthetic chemotactic tripeptide, formyl-Met-Leu-Phe. The minimal inhibitory concentrations for PGE1, PGE2 and PGF2.alpha. were 10-7, 10-6 and 10-5M, respectively. These results are similar to those found for the prostaglandin-induced inhibition of platelet aggregation. It may be that neutrophil aggregation, like platelet aggregation, is modulated by intracellular prostaglandins and other products of arachidonic acid metabolism.

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