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Effect of prostaglandin e 1 prostaglandin e 2 and prostaglandin f 2 alpha on the electric activity of the sphincter of oddi in living rabbit


, : Effect of prostaglandin e 1 prostaglandin e 2 and prostaglandin f 2 alpha on the electric activity of the sphincter of oddi in living rabbit. European Surgical Research 15(6): 322-327

The effect of prostaglandins (PG), i.e., PGE1, PGE2 and PGF2.alpha. (0.5-32 .mu.g/kg), on the electrical activity of the rabbit sphincter of Oddi was studied in vivo. PG were injected i.v. as a bolus and electrical activity of the sphincter and the duodenum was recorded before and during 15 min after the injection. Variations in biliary pressure were studied at the same time. PGE1 strongly decreased the activity of the sphincter and biliary pressure which were both increased by PGF2.alpha. Both PGE1 and PGF2.alpha. showed a dose-response curve of Michaelis-Menten type. PGE2 increased at first, then decreasesd electrical activity, but not significantly. These effects appeared very early after i.v. injection and were evident with low doses.

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