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Effect of prostaglandin inhibition on renin release comparison of furosemide and low sodium stimulation tests






Journal of Laboratory & Clinical Medicine 98(6): 929-937

Effect of prostaglandin inhibition on renin release comparison of furosemide and low sodium stimulation tests

Furosemide administration is considered comparable to Na restriction and upright posture as a stimulation test of PRA [plasma renin activity]. This view can be questioned if different mechanisms of renin release are involved. Prostaglandins appear to be an important mediator of renin release. Using a prostaglandin antagonist, indomethacin, the relative role of prostaglandins in the 2 renin stimulation tests was assessed. Eleven healthy volunteers on a high-Na intake had PRA and PA [plasma aldosterone] measured in response to furosemide stimulation before and during indomethacin administration and then in response to Na restriction combined with upright posture before and during indomethacin. Supine PRA was 0.41 ng/ml per h on high Na and 0.19 after indomethacin (P < 0.05). On low Na, the supine PRA was 2.07 ng/ml per h and 0.98 after indomethacin (P < 0.05). The increase in PRA (.DELTA.PRA) was 3.26 ng/ml per h with furosemide stimulation and 1.23 after indomethacin (P < 0.025). The PRA was 3.71 ng/ml per h with low-Na stimulation and upright posture and 2.53 after indomethacin (not significant). PA paralleled PRA except that there was no suppression of supine values with indomethacin. Prostaglandins apparently mediate baseline renin secretion and renin stimulation in response to furosemide. No comparable prostaglandin mediation could be demonstrated during renin stimulation secondary to Na restriction. The 2 standard renin stimulation tests appear to involve different mechanisms of renin release.


Accession: 005264950



Related references

Goldiner, W.H.; Valente, W.A.; Hamilton, B.P.; Mersey, J.H., 1981: The effect of prostaglandin inhibition on renin release. A comparison of furosemide and low-sodium stimulation tests. Furosemide administration is considered comparable to sodium restriction and upright posture as a stimulation test of PRA. This view can be questioned if different mechanisms of renin release are involved. Prostaglandins appear to be an important...

Weber P.C.; Scherer B.; Larsson C., 1977: Increased arachidonic acid release as the primary cause of furosemide induced stimulation of prostaglandin synthesis and renin release in man. Kidney International 11(3): 220-221

Barchowsky, A.; Data, J.L.; Whorton, A.R., 1984: The effect of prostaglandin synthesis inhibition on the direct stimulation of renin release from rabbit renal cortical slices. Prostaglandins have been hypothesized to have several mechanistic functions in sympathetically mediated release of renin. The rabbit renal cortical slice system was chosen to examine the prostaglandin dependency of renin release directly stimulate...

Barchowsky A.; Data J.L.; Whorton A.R., 1984: Effect of prostaglandin synthesis inhibition on the direct stimulation of renin release from rabbit renal cortical slices. Prostaglandins [PG] have been hypothesized to have several mechanistic functions in sympathetically-mediated release of renin. The rabbit renal cortical slice system was chosen to examine the PG dependency of renin release directly stimulated by e...

Sreenivasan V.; Walker B.; Mookerjee B.; Krasney J.; Venuto R., 1977: The effect of inhibitors of prostaglandin synthesis on furosemide induced renin release in conscious dogs. Kidney International 12(6): 474

Gerber J.G.; Keller R.T.; Nies A.S., 1979: Prostaglandins and renin release the effect of prostaglandin i 2 prostaglandin e 2 and 13 14 di hydro prostaglandin e 2 on the baro receptor mechanism of renin release in the dog. The abilities of the vasodilator prostaglandins PGI2, PGE2 and 13,14-dihydro PGE2 to release renin were compared when infused into the denervated, nonfiltering canine kidney in vivo. Papaverine was used as a nonprostaglandin vasodilator. All prost...

Weber P.C.; Scherer B.; Larsson C., 1978: Stimulation of renal prostaglandin e 2 9 keto reductase by high sodium chloride intake possible effect on prostaglandin renin interaction. Kidney International 13(6): 533

Sullivan, J.M.; Patrick, D.R., 1981: Release of prostaglandin I2-like activity from the rat aorta: effect of captopril, furosemide, and sodium. The effect of captopril, furosemide, indomethacin and intake of sodium on the production of PGI2-like material was studied in the rat aorta. Release of PGI2-like material from these vessels was estimated by its ability to inhibit ADP-induced plate...

Sullivan J.M., 1981: Release of prostaglandin i 2 like activity from blood vessels of the rat effect of captopril furosemide and sodium. American Heart Association Monograph (82): IV-284

Samuelsson B.II, 1976: Changes in renin release in vivo and in vitro following stimulation and inhibition of the renal prostaglandin synthetase system. European Journal Of Clinical Investigation: 327