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Effect of prostaglandin synthetase inhibitors on renal function studies in normal rats during sodium or water diuresis and in rats with chronic renal insufficiency

, : Effect of prostaglandin synthetase inhibitors on renal function studies in normal rats during sodium or water diuresis and in rats with chronic renal insufficiency. Prostaglandins 22(1): 1-10

The effect of acute infusion of the prostaglandin synthetase inhibitors, meclofenamate or indomethacin, was examined in awake rats. Studies were performed in normal rats undergoing either Na or H2O diuresis and in salt-replete rats with chronic renal insufficiency. Prostaglandin synthetase inhibitors had no effect on renal plasma flow, glomerular filtration rate or fractional excretion of Na in any of the groups. Absolute urinary excretion rates for Na and K decreased only in the normal, salt-replete rats. Prostaglandin synthetase inhibitors consistently decreased urinary flow and osmolar clearance under all experimental conditions studied. In the normal, salt-replete rats the fall in urine flow was preceded by an increase in urinary excretion of cAMP. Inhibitors of prostaglandin synthesis apparently enhance the ability of the kidney to reabsorb H2O. This effect may be secondary to increased cAMP generation and to increased urea recirculation resulting in higher urea accumulation in the renal medulla.

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