Section 6
Chapter 5,267

Effect of reduction and alkylation on the antigenicity of cartilage proteoglycans

Sugahara, K.; Dorfman, A.

Biochemical and Biophysical Research Communications 89(4): 1193-1199


ISSN/ISBN: 0006-291X
PMID: 91369
DOI: 10.1016/0006-291x(79)92134-x
Accession: 005266410

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Immunological studies were performed on the proteoglycans from chick epiphyseal cartilage and rat chondrosarcoma. Immunodiffusion and direct radioimmune precipitation assays indicated that each proteoglycan subunit had species-specific and species-common antigenic determinants. Reduction and alkylation abolished the antigenicity of the species-specific antigenic determinants of both proteoglycan preparations as determined by immunodiffusion and radioimmune inhibition assays. Some, not all, of the species-common antigenic determinants also were sensitive to the treatment.

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