Effect of selenium on azoxymethane-induced intestinal cancer in rats fed high fat diet
Soullier, B.K.; Wilson, P.S.; Nigro, N.D.
Cancer Letters 12(4): 343-348
The effects of Se supplementation on azoxymethane-induced intestinal cancer were studied in male Sprague-Dawley rats given 8 weekly injections of azoxymethane (8 mg/kg body wt) and fed a 30% beef fat diet. Se supplemented groups received 8 ppm H2SeO3 in drinking water. Blood Se levels of supplemented rats rapidly increased the first 9 wk of the experiment, followed by a plateau significantly higher than that for non-selenium controls. There was a significant increase in liver and intestinal Se levels in supplemented groups. The average number of intestinal tumors was 6.5 in the control group and 3.1 in the Se supplemented group. There was a significant reduction in tumor incidence in the proximal half of the colon of Se-treated rats. There was also increased concentration of tissue Se in the proximal half of the colon of these rats.