Effect of succunylcholine and pancuronium on intraocular pressure and aqueous outflow

Tanifuji, Y.; Sugahara, Y.; Mashiko, K.; Kobayashi, K.; Saito, T.

Masui. Japanese Journal of Anesthesiology 31(6): 600-604


ISSN/ISBN: 0021-4892
PMID: 7131734
Accession: 005273452

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The effect of succinylcholine chloride (Sch) and pancuronium bromide on intraocular pressure (IOP) and aqueous outflow was investigated in 24 patients undergoing surgical operation. They were anesthetized with halothane in O2 and ventilated automatically to maintain end-tidal CO2 at 4-5%. Measurements of IOP and rate of aqueous outflow were performed as follows: before anesthesia; on 1, MAC halothane; 10 min after the start of Sch 0.5 mg/kg per min drip in infusion under 1 MAC halothane; 5 min after pancuronium 0.1 mg/kg bolus infusion, under 1 MAC halothane; and 3, 5, 10 and 15 min after Sch 1 mg/kg bolus infusion. On 1 MAC halothane IOP decreased significantly by 20%. Ten min after the disappearance of fasciculation with Sch drip infusion, IOP increased significantly by 30% and its increase continued until the stop of infusion. IOP was unchanged by pancuronium bromide. The rate of aqueous outflow was unchanged at 1 MAC halothane and pancuronium bromide infusion. Sch drip infusion decreased aqueous outflow significantly in 21%. Evidently, the increase in IOP is not related to fasciculation but is caused by the decrease of aqueous outflow.