Effect of the liver function correction on the development of 7 12 dimethylbenz a anthracene induced mammary gland tumors and metabolism of sex steroid hormones in rats

Golotyuk, S.I.

Eksperimental'naya Onkologiya 9(4): 51-53

1987


ISSN/ISBN: 0204-3564
Accession: 005277018

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Abstract
The tumours of mammary glands in Wistar rat females were induced by threefold intravenous administration of 7,12-dimethylbenz(a)anthracene (DMBA). The application of pharmacological preparations contributing to the liver function correction (DCLF) in the process of carcinogenesis and during the surgical treatment of mammary tumours leads to prolongation of the first tumour latent period after DMBA administration and of recurrent tumours after the operation. The lowering of the frequency, multiplicity and the rate of mammary tumours growth were also observed. The use of PCLF exerted a normalizing effect on the level of sex steroid hormones in rats.