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Effect of therapy on blood serum lipids and prolonged fenofibrate lipoproteins in patients with hypercholesterolemia and hypertriglyceridemia


Effect of therapy on blood serum lipids and prolonged fenofibrate lipoproteins in patients with hypercholesterolemia and hypertriglyceridemia



Polski Tygodnik Lekarski 41(51-52): 1633-1637



ISSN/ISBN: 0032-3756

An effect of a 3-year treatment with fenofibrate was evaluated in 35 patients with hypertrigliceridemia. Serum total cholesterol, LDL + VLDL or LDL, HDL and ratio LDL + VLDL/HDL or LDL/HDL were determined. The same parameters were determined in 20 patients with heterozygotic inherited hypercholesterolemia treated for 2 years. A significant decrease in total cholesterol concentration, LDL cholesterol or LDL + VLDL, LDL + VLDL/HDL or LDL/HDL ratio; and in triglycerides was seen in all examined patients. A significant increase in HDL-cholesterol was observed in patients with hypertriglyceridemia while it remained unchanged in hypercholesterolemia. The obtained results suggest that fenofibrate exerts hypolipemic action during chronic administration. The drug may be an alternative therapy to cholestyramine in some cases in monogenic forms of hypercholesterolemia due to its efficacy.

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Accession: 005278052

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