Effect of thyroid hormones on protein synthesis in microsomes in vitro

Rachev, R.R.; Dimitrov, M.I.

Voprosy Meditsinskoi Khimii 25(1): 20-26


ISSN/ISBN: 0042-8809
PMID: 425368
Accession: 005278562

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I2 and ICl were shown to possess the thyroxin-like effect on protein synthesis in microsomes, isolated from liver tissue of young thyroidectomized rats and incubated in the medium containing 3H-glycine and 1-14C-leucine. Triiodothyronine and iodine-containing substances increased 3.5--3.9-fold the incorporation of these labelled amino acids into microsomal proteins as compared with untreated microsomes from thyroidectomized rats. Olivomycin and cycloheximide abolished the stimulating effect of T3 and iodine ions on the protein synthesis in microsomes. ICl exhibited a distinctly shorter, as compared with T3, latent period of action on the protein synthesis in microsomes of thyroidectomized animals.