Effect of thyroid hormones on the activities of hepatic alcohol metabolizing enzymes

Moreno, F.; Teschke, R.; Strohmeyer, G.

Biochemical and Biophysical Research Communications 89(3): 806-812


ISSN/ISBN: 0006-291X
PMID: 486198
DOI: 10.1016/0006-291x(79)91850-3
Accession: 005278565

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Treatment with thyroxine or triiodothyronine for 7 days to simulate a hyperthyroid state results in an enhanced activity of the microsomal ethanol oxidizing system. A decrease of hepatic alcohol dehydrogenase activity was observed under these experimental conditions, whereas hepatic catalase activity remained unchanged. If chronic ethanol consumption simulates a hyperthyroid hepatic state, increased rates of ethanol metabolism observed following prolonged alcohol intake may be attributed partly to an induction of microsomal ethanol oxidizing system activity in the liver.