Effect of topical 0.5 percent triamterene suspension on the intra ocular pressure of open angle glaucoma patients a single dose study
Mills, K.B.; Gilbert, D.J.; Ridgway, A.E.A.
Current Eye Research 3(2): 273-278
ISSN/ISBN: 0271-3683 Accession: 005279100
The effect of a topical 0.5% triamterene suspension on the intraocular pressure of 15 open angle glaucoma patients was investigated. On the 1st day measurements were made at 09.00, 12.00 and 16.30 h without treatment. On the 2nd day measurements were made at 09.00 h and 1, 2, 4 and 6 h following instillation of the suspension into the eye. Without treatment there were no significant changes in intraocular pressure. After topical triamterene the maximum group mean pressure reduction was -4.7 mm Hg at 6 h and mean intraocular pressures were less than 22 mm Hg at both 4 and 6 h. There was also a notable decrease in intraocular pressure in 2/3 of the contralateral untreated eyes which was not attributable to diurnal variation. No local or systemic side effects were observed.