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Effect of tumor cells on the generation of cyto toxic thymus derived lymphocytes in vitro part 1 accessory cell functions of mouse tumor cells in the generation of cyto toxic thymus derived lymphocytes in vitro replacement of adherent phagocytic cells by tumor cells or 2 mercapto ethanol



Effect of tumor cells on the generation of cyto toxic thymus derived lymphocytes in vitro part 1 accessory cell functions of mouse tumor cells in the generation of cyto toxic thymus derived lymphocytes in vitro replacement of adherent phagocytic cells by tumor cells or 2 mercapto ethanol



European Journal of Immunology 7(6): 394-400



In agreement with previous reports, the primary in vitro response to alloantigens was shown to be dependent on the presence of macrophages (Mphs). Splenocytes extensively depleted of adherent phagocytic cells did not generate cytotoxic T [thymus-derived] lymphocytes, and this activity could be completely restored by small numbers of adherent peritoneal cells (accessory cells). P388D1 [leukemia] (Mph-like tumor), P388 (null tumor) or P815 (mastocytoma) tumor cells, or 2-mercaptoethanol, could completely replace the accessory function normally mediated by accessory cells. These tumor cells did not nonspecifically enhance the cytotoxic activity generated with normal nondepleted spleen cells. The restored cultures maintained killing specificity to H-2 targets which was mediated by effector T cells as shown by sensitivity ot anti-.tau. and complement. Mphs seem not to be the sole cells capable of mediating an accessory function in a primary response to alloantigens in vitro.

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Accession: 005280108

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