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Effect of x irradiation on the nuclear dna content and size of the nuclei in regenerating rat liver



Effect of x irradiation on the nuclear dna content and size of the nuclei in regenerating rat liver



Byulleten' Eksperimental'noi Biologii i Meditsiny 91(4): 490-492



Cytophotometry was used to study changes in the nuclear DNA content and nuclear size in regenerating liver of rats exposed to 154.8 mC/kg (600 R) of X-irradiation 10-30 min before partial hepatectomy. The irradiated and non-irradiated animals were examined 18h to 21 days after partial hepatectomy. For 30 h after partial hepatectomy the increase in the nuclear DNA content was prevented by irradiation. As compared with the non-irradiated animals, the increase in the DNA content in the nucleus was 12-18 h later and occurred in fewer cells. Enlargement of the nuclear size in the irradiated animals, mainly on the 48th h after partial hepatectomy, was not accompanied by the respective increment of the DNA content.

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Accession: 005283161

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